Fig 1: Enrichment plot: HALLMARK_XENOBIOTIC_METABOLISM
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_pos |
| GeneSet | HALLMARK_XENOBIOTIC_METABOLISM |
| Enrichment Score (ES) | 0.26357576 |
| Normalized Enrichment Score (NES) | 0.7922824 |
| Nominal p-value | 0.7520325 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.979 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | MCCC2 | MCCC2 Entrez, Source | methylcrotonoyl-Coenzyme A carboxylase 2 (beta) | 65 | 0.271 | 0.0292 | Yes |
| 2 | ECH1 | ECH1 Entrez, Source | enoyl Coenzyme A hydratase 1, peroxisomal | 78 | 0.248 | 0.1410 | Yes |
| 3 | CYP1A2 | CYP1A2 Entrez, Source | cytochrome P450, family 1, subfamily A, polypeptide 2 | 151 | 0.163 | 0.0997 | Yes |
| 4 | SLC1A5 | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 173 | 0.140 | 0.1373 | Yes |
| 5 | SLC12A4 | SLC12A4 Entrez, Source | solute carrier family 12 (potassium/chloride transporters), member 4 | 175 | 0.137 | 0.2092 | Yes |
| 6 | NPC1 | NPC1 Entrez, Source | Niemann-Pick disease, type C1 | 228 | 0.093 | 0.1666 | Yes |
| 7 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 236 | 0.088 | 0.2011 | Yes |
| 8 | PAPSS2 | PAPSS2 Entrez, Source | 3'-phosphoadenosine 5'-phosphosulfate synthase 2 | 253 | 0.074 | 0.2123 | Yes |
| 9 | ASL | ASL Entrez, Source | argininosuccinate lyase | 262 | 0.064 | 0.2322 | Yes |
| 10 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 264 | 0.062 | 0.2636 | Yes |
| 11 | APOE | APOE Entrez, Source | apolipoprotein E | 281 | 0.047 | 0.2600 | No |
| 12 | MT2A | MT2A Entrez, Source | metallothionein 2A | 328 | 0.009 | 0.1828 | No |
| 13 | DHRS7 | DHRS7 Entrez, Source | dehydrogenase/reductase (SDR family) member 7 | 353 | -0.005 | 0.1428 | No |
| 14 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 355 | -0.006 | 0.1442 | No |
| 15 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 371 | -0.019 | 0.1275 | No |
| 16 | GSS | GSS Entrez, Source | glutathione synthetase | 428 | -0.069 | 0.0645 | No |
| 17 | DDT | DDT Entrez, Source | D-dopachrome tautomerase | 452 | -0.091 | 0.0722 | No |
| 18 | CYP2J2 | CYP2J2 Entrez, Source | cytochrome P450, family 2, subfamily J, polypeptide 2 | 488 | -0.130 | 0.0797 | No |
| 19 | PDLIM5 | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 508 | -0.148 | 0.1250 | No |
