Fig 1: Enrichment plot: HALLMARK_TNFA_SIGNALING_VIA_NFKB
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_neg |
| GeneSet | HALLMARK_TNFA_SIGNALING_VIA_NFKB |
| Enrichment Score (ES) | -0.3207267 |
| Normalized Enrichment Score (NES) | -0.8317087 |
| Nominal p-value | 0.6385069 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.97 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EIF1 | EIF1 Entrez, Source | eukaryotic translation initiation factor 1 | 105 | 0.214 | -0.0622 | No |
| 2 | B4GALT5 | B4GALT5 Entrez, Source | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 183 | 0.132 | -0.1226 | No |
| 3 | MCL1 | MCL1 Entrez, Source | myeloid cell leukemia sequence 1 (BCL2-related) | 214 | 0.106 | -0.1144 | No |
| 4 | RNF19B | 245 | 0.081 | -0.1209 | No | ||
| 5 | IL6ST | IL6ST Entrez, Source | interleukin 6 signal transducer (gp130, oncostatin M receptor) | 261 | 0.065 | -0.1098 | No |
| 6 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 264 | 0.062 | -0.0775 | No |
| 7 | GCH1 | GCH1 Entrez, Source | GTP cyclohydrolase 1 (dopa-responsive dystonia) | 355 | -0.006 | -0.2342 | No |
| 8 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 361 | -0.011 | -0.2367 | No |
| 9 | SNN | SNN Entrez, Source | stannin | 403 | -0.045 | -0.2834 | Yes |
| 10 | NFKB1 | NFKB1 Entrez, Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 421 | -0.064 | -0.2762 | Yes |
| 11 | NFAT5 | NFAT5 Entrez, Source | nuclear factor of activated T-cells 5, tonicity-responsive | 447 | -0.083 | -0.2726 | Yes |
| 12 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 450 | -0.084 | -0.2274 | Yes |
| 13 | DUSP5 | DUSP5 Entrez, Source | dual specificity phosphatase 5 | 474 | -0.118 | -0.1994 | Yes |
| 14 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 500 | -0.136 | -0.1647 | Yes |
| 15 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 507 | -0.144 | -0.0917 | Yes |
| 16 | PDLIM5 | PDLIM5 Entrez, Source | PDZ and LIM domain 5 | 508 | -0.148 | -0.0059 | Yes |
| 17 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 552 | -0.221 | 0.0463 | Yes |
