Fig 1: Enrichment plot: HALLMARK_P53_PATHWAY
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_pos |
| GeneSet | HALLMARK_P53_PATHWAY |
| Enrichment Score (ES) | 0.32138887 |
| Normalized Enrichment Score (NES) | 0.9507487 |
| Nominal p-value | 0.5182342 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.936 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | RXRA | RXRA Entrez, Source | retinoid X receptor, alpha | 53 | 0.289 | 0.0444 | Yes |
| 2 | GM2A | GM2A Entrez, Source | GM2 ganglioside activator | 90 | 0.233 | 0.0924 | Yes |
| 3 | BAX | BAX Entrez, Source | BCL2-associated X protein | 136 | 0.181 | 0.0991 | Yes |
| 4 | RPL18 | RPL18 Entrez, Source | ribosomal protein L18 | 140 | 0.178 | 0.1793 | Yes |
| 5 | RPS12 | RPS12 Entrez, Source | ribosomal protein S12 | 159 | 0.153 | 0.2206 | Yes |
| 6 | HINT1 | HINT1 Entrez, Source | histidine triad nucleotide binding protein 1 | 163 | 0.147 | 0.2859 | Yes |
| 7 | CEBPA | CEBPA Entrez, Source | CCAAT/enhancer binding protein (C/EBP), alpha | 180 | 0.133 | 0.3214 | Yes |
| 8 | RNF19B | 245 | 0.081 | 0.2462 | No | ||
| 9 | ACVR1B | ACVR1B Entrez, Source | activin A receptor, type IB | 336 | 0.004 | 0.0880 | No |
| 10 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 361 | -0.011 | 0.0506 | No |
| 11 | TXNIP | TXNIP Entrez, Source | thioredoxin interacting protein | 377 | -0.024 | 0.0356 | No |
| 12 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 396 | -0.039 | 0.0220 | No |
| 13 | CCND2 | CCND2 Entrez, Source | cyclin D2 | 397 | -0.040 | 0.0413 | No |
| 14 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 422 | -0.065 | 0.0296 | No |
| 15 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 451 | -0.090 | 0.0228 | No |
| 16 | ISCU | 542 | -0.195 | -0.0439 | No | ||
| 17 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 552 | -0.221 | 0.0463 | No |
