Fig 1: Enrichment plot: HALLMARK_MYOGENESIS
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_neg |
| GeneSet | HALLMARK_MYOGENESIS |
| Enrichment Score (ES) | -0.22082682 |
| Normalized Enrichment Score (NES) | -0.6287006 |
| Nominal p-value | 0.902834 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.994 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 17 | 0.364 | 0.0997 | No |
| 2 | EPHB3 | EPHB3 Entrez, Source | EPH receptor B3 | 66 | 0.270 | 0.1103 | No |
| 3 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 93 | 0.226 | 0.1447 | No |
| 4 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 143 | 0.176 | 0.1198 | No |
| 5 | NCAM1 | NCAM1 Entrez, Source | neural cell adhesion molecule 1 | 194 | 0.121 | 0.0735 | No |
| 6 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 242 | 0.084 | 0.0193 | No |
| 7 | ERBB3 | ERBB3 Entrez, Source | v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) | 251 | 0.076 | 0.0323 | No |
| 8 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 272 | 0.054 | 0.0158 | No |
| 9 | PTGIS | PTGIS Entrez, Source | prostaglandin I2 (prostacyclin) synthase | 307 | 0.026 | -0.0359 | No |
| 10 | HSPB2 | HSPB2 Entrez, Source | heat shock 27kDa protein 2 | 308 | 0.025 | -0.0268 | No |
| 11 | FABP3 | FABP3 Entrez, Source | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | 338 | 0.004 | -0.0774 | No |
| 12 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 396 | -0.039 | -0.1658 | No |
| 13 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 422 | -0.065 | -0.1875 | Yes |
| 14 | CACNG1 | CACNG1 Entrez, Source | calcium channel, voltage-dependent, gamma subunit 1 | 425 | -0.067 | -0.1670 | Yes |
| 15 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 450 | -0.084 | -0.1800 | Yes |
| 16 | RB1 | RB1 Entrez, Source | retinoblastoma 1 (including osteosarcoma) | 451 | -0.090 | -0.1480 | Yes |
| 17 | MEF2A | MEF2A Entrez, Source | MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) | 492 | -0.132 | -0.1724 | Yes |
| 18 | ADCY9 | ADCY9 Entrez, Source | adenylate cyclase 9 | 520 | -0.161 | -0.1632 | Yes |
| 19 | COL6A3 | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 540 | -0.190 | -0.1294 | Yes |
| 20 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 552 | -0.221 | -0.0699 | Yes |
| 21 | COX7A1 | COX7A1 Entrez, Source | cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) | 573 | -0.321 | 0.0090 | Yes |
