Fig 1: Enrichment plot: HALLMARK_MYC_TARGETS_V1
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_pos |
| GeneSet | HALLMARK_MYC_TARGETS_V1 |
| Enrichment Score (ES) | 0.68624645 |
| Normalized Enrichment Score (NES) | 1.6889254 |
| Nominal p-value | 0.01369863 |
| FDR q-value | 0.12892295 |
| FWER p-Value | 0.114 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | EIF4G2 | EIF4G2 Entrez, Source | eukaryotic translation initiation factor 4 gamma, 2 | 0 | 1.000 | 0.1637 | Yes |
| 2 | CCNA2 | CCNA2 Entrez, Source | cyclin A2 | 4 | 0.418 | 0.2268 | Yes |
| 3 | HDGF | HDGF Entrez, Source | hepatoma-derived growth factor (high-mobility group protein 1-like) | 6 | 0.393 | 0.2894 | Yes |
| 4 | ILF2 | ILF2 Entrez, Source | interleukin enhancer binding factor 2, 45kDa | 15 | 0.372 | 0.3360 | Yes |
| 5 | STARD7 | STARD7 Entrez, Source | START domain containing 7 | 18 | 0.363 | 0.3919 | Yes |
| 6 | TARDBP | TARDBP Entrez, Source | TAR DNA binding protein | 22 | 0.346 | 0.4432 | Yes |
| 7 | SLC25A3 | SLC25A3 Entrez, Source | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 30 | 0.331 | 0.4847 | Yes |
| 8 | CANX | CANX Entrez, Source | calnexin | 33 | 0.328 | 0.5348 | Yes |
| 9 | HNRNPA1 | 51 | 0.290 | 0.5518 | Yes | ||
| 10 | MCM4 | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 54 | 0.287 | 0.5952 | Yes |
| 11 | PSMB2 | PSMB2 Entrez, Source | proteasome (prosome, macropain) subunit, beta type, 2 | 62 | 0.275 | 0.6277 | Yes |
| 12 | DUT | DUT Entrez, Source | dUTP pyrophosphatase | 75 | 0.252 | 0.6474 | Yes |
| 13 | HSP90AB1 | HSP90AB1 Entrez, Source | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 77 | 0.248 | 0.6862 | Yes |
| 14 | RPL6 | RPL6 Entrez, Source | ribosomal protein L6 | 113 | 0.203 | 0.6567 | No |
| 15 | RNPS1 | RNPS1 Entrez, Source | RNA binding protein S1, serine-rich domain | 117 | 0.198 | 0.6837 | No |
| 16 | RPL18 | RPL18 Entrez, Source | ribosomal protein L18 | 140 | 0.178 | 0.6735 | No |
| 17 | RPS5 | RPS5 Entrez, Source | ribosomal protein S5 | 161 | 0.148 | 0.6620 | No |
| 18 | AP3S1 | AP3S1 Entrez, Source | adaptor-related protein complex 3, sigma 1 subunit | 277 | 0.049 | 0.4639 | No |
| 19 | NCBP2 | NCBP2 Entrez, Source | nuclear cap binding protein subunit 2, 20kDa | 374 | -0.023 | 0.2956 | No |
| 20 | RPL34 | RPL34 Entrez, Source | ribosomal protein L34 | 493 | -0.133 | 0.1058 | No |
| 21 | PRPS2 | PRPS2 Entrez, Source | phosphoribosyl pyrophosphate synthetase 2 | 568 | -0.273 | 0.0179 | No |
