Fig 1: Enrichment plot: HALLMARK_MTORC1_SIGNALING
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_neg |
| GeneSet | HALLMARK_MTORC1_SIGNALING |
| Enrichment Score (ES) | -0.3345657 |
| Normalized Enrichment Score (NES) | -0.93297774 |
| Nominal p-value | 0.5672878 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.952 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | CANX | CANX Entrez, Source | calnexin | 33 | 0.328 | 0.0722 | No |
| 2 | MCM4 | MCM4 Entrez, Source | MCM4 minichromosome maintenance deficient 4 (S. cerevisiae) | 54 | 0.287 | 0.1512 | No |
| 3 | SLC37A4 | SLC37A4 Entrez, Source | solute carrier family 37 (glycerol-6-phosphate transporter), member 4 | 135 | 0.182 | 0.0815 | No |
| 4 | PGM1 | PGM1 Entrez, Source | phosphoglucomutase 1 | 156 | 0.154 | 0.1075 | No |
| 5 | SLC1A5 | SLC1A5 Entrez, Source | solute carrier family 1 (neutral amino acid transporter), member 5 | 173 | 0.140 | 0.1349 | No |
| 6 | LTA4H | LTA4H Entrez, Source | leukotriene A4 hydrolase | 268 | 0.059 | -0.0088 | No |
| 7 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 323 | 0.015 | -0.0989 | No |
| 8 | PLOD2 | PLOD2 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 324 | 0.013 | -0.0936 | No |
| 9 | GBE1 | GBE1 Entrez, Source | glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) | 415 | -0.058 | -0.2305 | No |
| 10 | GTF2H1 | GTF2H1 Entrez, Source | general transcription factor IIH, polypeptide 1, 62kDa | 417 | -0.061 | -0.2080 | No |
| 11 | CORO1A | CORO1A Entrez, Source | coronin, actin binding protein, 1A | 443 | -0.075 | -0.2225 | No |
| 12 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 507 | -0.144 | -0.2771 | Yes |
| 13 | SRD5A1 | SRD5A1 Entrez, Source | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | 518 | -0.158 | -0.2319 | Yes |
| 14 | GLRX | GLRX Entrez, Source | glutaredoxin (thioltransferase) | 532 | -0.181 | -0.1826 | Yes |
| 15 | SLA | SLA Entrez, Source | Src-like-adaptor | 534 | -0.182 | -0.1118 | Yes |
| 16 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 552 | -0.221 | -0.0537 | Yes |
| 17 | ACTR3 | ACTR3 Entrez, Source | ARP3 actin-related protein 3 homolog (yeast) | 562 | -0.246 | 0.0285 | Yes |
