Fig 1: Enrichment plot: HALLMARK_HYPOXIA
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_neg |
| GeneSet | HALLMARK_HYPOXIA |
| Enrichment Score (ES) | -0.37499017 |
| Normalized Enrichment Score (NES) | -1.0353217 |
| Nominal p-value | 0.4011976 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.906 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HEXA | HEXA Entrez, Source | hexosaminidase A (alpha polypeptide) | 134 | 0.186 | -0.1383 | No |
| 2 | SLC37A4 | SLC37A4 Entrez, Source | solute carrier family 37 (glycerol-6-phosphate transporter), member 4 | 135 | 0.182 | -0.0399 | No |
| 3 | PGM1 | PGM1 Entrez, Source | phosphoglucomutase 1 | 156 | 0.154 | 0.0080 | No |
| 4 | LOX | LOX Entrez, Source | lysyl oxidase | 254 | 0.074 | -0.1254 | No |
| 5 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 264 | 0.062 | -0.1080 | No |
| 6 | PIM1 | PIM1 Entrez, Source | pim-1 oncogene | 292 | 0.034 | -0.1378 | No |
| 7 | PAM | PAM Entrez, Source | peptidylglycine alpha-amidating monooxygenase | 296 | 0.032 | -0.1259 | No |
| 8 | MT2A | MT2A Entrez, Source | metallothionein 2A | 328 | 0.009 | -0.1763 | No |
| 9 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 356 | -0.008 | -0.2204 | No |
| 10 | BTG1 | BTG1 Entrez, Source | B-cell translocation gene 1, anti-proliferative | 361 | -0.011 | -0.2216 | No |
| 11 | XPNPEP1 | XPNPEP1 Entrez, Source | X-prolyl aminopeptidase (aminopeptidase P) 1, soluble | 362 | -0.012 | -0.2151 | No |
| 12 | WSB1 | WSB1 Entrez, Source | WD repeat and SOCS box-containing 1 | 366 | -0.016 | -0.2118 | No |
| 13 | GBE1 | GBE1 Entrez, Source | glucan (1,4-alpha-), branching enzyme 1 (glycogen branching enzyme, Andersen disease, glycogen storage disease type IV) | 415 | -0.058 | -0.2661 | No |
| 14 | CAV1 | CAV1 Entrez, Source | caveolin 1, caveolae protein, 22kDa | 477 | -0.119 | -0.3107 | Yes |
| 15 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 500 | -0.136 | -0.2763 | Yes |
| 16 | SLC2A3 | SLC2A3 Entrez, Source | solute carrier family 2 (facilitated glucose transporter), member 3 | 507 | -0.144 | -0.2090 | Yes |
| 17 | GLRX | GLRX Entrez, Source | glutaredoxin (thioltransferase) | 532 | -0.181 | -0.1538 | Yes |
| 18 | GAPDHS | GAPDHS Entrez, Source | glyceraldehyde-3-phosphate dehydrogenase, spermatogenic | 548 | -0.208 | -0.0681 | Yes |
| 19 | CDKN1A | CDKN1A Entrez, Source | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 552 | -0.221 | 0.0464 | Yes |
