Fig 1: Enrichment plot: HALLMARK_HEME_METABOLISM
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_pos |
| GeneSet | HALLMARK_HEME_METABOLISM |
| Enrichment Score (ES) | 0.34152812 |
| Normalized Enrichment Score (NES) | 0.9873052 |
| Nominal p-value | 0.4681725 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.926 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | HDGF | HDGF Entrez, Source | hepatoma-derived growth factor (high-mobility group protein 1-like) | 6 | 0.393 | 0.1457 | Yes |
| 2 | TFDP2 | TFDP2 Entrez, Source | transcription factor Dp-2 (E2F dimerization partner 2) | 29 | 0.333 | 0.2388 | Yes |
| 3 | HAGH | HAGH Entrez, Source | hydroxyacylglutathione hydrolase | 69 | 0.261 | 0.2734 | Yes |
| 4 | ADD2 | ADD2 Entrez, Source | adducin 2 (beta) | 104 | 0.216 | 0.2989 | Yes |
| 5 | NCOA4 | NCOA4 Entrez, Source | nuclear receptor coactivator 4 | 124 | 0.192 | 0.3415 | Yes |
| 6 | H1F0 | H1F0 Entrez, Source | H1 histone family, member 0 | 177 | 0.135 | 0.3027 | No |
| 7 | ARL2BP | ARL2BP Entrez, Source | ADP-ribosylation factor-like 2 binding protein | 192 | 0.125 | 0.3274 | No |
| 8 | ICAM4 | ICAM4 Entrez, Source | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) | 347 | -0.002 | 0.0545 | No |
| 9 | MXI1 | MXI1 Entrez, Source | MAX interactor 1 | 356 | -0.008 | 0.0433 | No |
| 10 | CA2 | CA2 Entrez, Source | carbonic anhydrase II | 371 | -0.019 | 0.0259 | No |
| 11 | CA1 | CA1 Entrez, Source | carbonic anhydrase I | 375 | -0.023 | 0.0297 | No |
| 12 | BACH1 | BACH1 Entrez, Source | BTB and CNC homology 1, basic leucine zipper transcription factor 1 | 399 | -0.042 | 0.0055 | No |
| 13 | NUDT4 | NUDT4 Entrez, Source | nudix (nucleoside diphosphate linked moiety X)-type motif 4 | 408 | -0.051 | 0.0114 | No |
| 14 | RIOK3 | RIOK3 Entrez, Source | RIO kinase 3 (yeast) | 485 | -0.129 | -0.0724 | No |
| 15 | E2F2 | E2F2 Entrez, Source | E2F transcription factor 2 | 564 | -0.258 | -0.1084 | No |
| 16 | OPTN | OPTN Entrez, Source | optineurin | 575 | -0.331 | 0.0053 | No |
