Fig 1: Enrichment plot: HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_neg |
| GeneSet | HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION |
| Enrichment Score (ES) | -0.18241812 |
| Normalized Enrichment Score (NES) | -0.41217074 |
| Nominal p-value | 0.9414141 |
| FDR q-value | 0.9910254 |
| FWER p-Value | 1.0 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | FSTL3 | FSTL3 Entrez, Source | follistatin-like 3 (secreted glycoprotein) | 14 | 0.380 | 0.0720 | Yes |
| 2 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 17 | 0.364 | 0.1620 | Yes |
| 3 | SPARC | SPARC Entrez, Source | secreted protein, acidic, cysteine-rich (osteonectin) | 93 | 0.226 | 0.0824 | No |
| 4 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 165 | 0.147 | -0.0103 | No |
| 5 | FERMT2 | 195 | 0.120 | -0.0326 | No | ||
| 6 | RGS4 | RGS4 Entrez, Source | regulator of G-protein signalling 4 | 201 | 0.113 | -0.0127 | No |
| 7 | VIM | VIM Entrez, Source | vimentin | 209 | 0.107 | 0.0020 | No |
| 8 | FN1 | FN1 Entrez, Source | fibronectin 1 | 230 | 0.092 | -0.0111 | No |
| 9 | IGFBP4 | IGFBP4 Entrez, Source | insulin-like growth factor binding protein 4 | 236 | 0.088 | 0.0023 | No |
| 10 | TPM1 | TPM1 Entrez, Source | tropomyosin 1 (alpha) | 239 | 0.085 | 0.0206 | No |
| 11 | COL3A1 | COL3A1 Entrez, Source | collagen, type III, alpha 1 (Ehlers-Danlos syndrome type IV, autosomal dominant) | 242 | 0.084 | 0.0385 | No |
| 12 | LOX | LOX Entrez, Source | lysyl oxidase | 254 | 0.074 | 0.0373 | No |
| 13 | SERPINE1 | SERPINE1 Entrez, Source | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 264 | 0.062 | 0.0366 | No |
| 14 | ITGB5 | ITGB5 Entrez, Source | integrin, beta 5 | 272 | 0.054 | 0.0377 | No |
| 15 | ACTA2 | ACTA2 Entrez, Source | actin, alpha 2, smooth muscle, aorta | 291 | 0.037 | 0.0142 | No |
| 16 | CXCL12 | CXCL12 Entrez, Source | chemokine (C-X-C motif) ligand 12 (stromal cell-derived factor 1) | 294 | 0.033 | 0.0190 | No |
| 17 | THBS1 | THBS1 Entrez, Source | thrombospondin 1 | 313 | 0.023 | -0.0081 | No |
| 18 | PLOD2 | PLOD2 Entrez, Source | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 324 | 0.013 | -0.0231 | No |
| 19 | EMP3 | EMP3 Entrez, Source | epithelial membrane protein 3 | 385 | -0.030 | -0.1257 | No |
| 20 | TGFB1 | TGFB1 Entrez, Source | transforming growth factor, beta 1 (Camurati-Engelmann disease) | 396 | -0.039 | -0.1341 | No |
| 21 | VEGFC | VEGFC Entrez, Source | vascular endothelial growth factor C | 402 | -0.045 | -0.1318 | No |
| 22 | FMOD | FMOD Entrez, Source | fibromodulin | 414 | -0.057 | -0.1374 | No |
| 23 | CALD1 | CALD1 Entrez, Source | caldesmon 1 | 416 | -0.061 | -0.1236 | No |
| 24 | ITGB3 | ITGB3 Entrez, Source | integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | 449 | -0.084 | -0.1608 | No |
| 25 | GADD45B | GADD45B Entrez, Source | growth arrest and DNA-damage-inducible, beta | 450 | -0.084 | -0.1392 | No |
| 26 | HTRA1 | HTRA1 Entrez, Source | HtrA serine peptidase 1 | 461 | -0.103 | -0.1310 | No |
| 27 | PDGFRB | PDGFRB Entrez, Source | platelet-derived growth factor receptor, beta polypeptide | 470 | -0.113 | -0.1166 | No |
| 28 | LUM | LUM Entrez, Source | lumican | 479 | -0.120 | -0.1004 | No |
| 29 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 480 | -0.123 | -0.0687 | No |
| 30 | THBS2 | THBS2 Entrez, Source | thrombospondin 2 | 487 | -0.130 | -0.0462 | No |
| 31 | CYR61 | CYR61 Entrez, Source | cysteine-rich, angiogenic inducer, 61 | 500 | -0.136 | -0.0332 | No |
| 32 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 502 | -0.138 | 0.0004 | No |
| 33 | SCG2 | SCG2 Entrez, Source | secretogranin II (chromogranin C) | 505 | -0.141 | 0.0330 | No |
| 34 | CAP2 | CAP2 Entrez, Source | CAP, adenylate cyclase-associated protein, 2 (yeast) | 539 | -0.189 | 0.0210 | No |
| 35 | COL6A3 | COL6A3 Entrez, Source | collagen, type VI, alpha 3 | 540 | -0.190 | 0.0699 | No |
