Fig 1: Enrichment plot: HALLMARK_APICAL_JUNCTION
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List
| Dataset | GSE19161_collapsed_to_symbols.GSE19161.cls#EIF4G2 |
| Phenotype | GSE19161.cls#EIF4G2 |
| Upregulated in class | EIF4G2_pos |
| GeneSet | HALLMARK_APICAL_JUNCTION |
| Enrichment Score (ES) | 0.27040273 |
| Normalized Enrichment Score (NES) | 0.855956 |
| Nominal p-value | 0.66468257 |
| FDR q-value | 1.0 |
| FWER p-Value | 0.969 |
| PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
|---|---|---|---|---|---|---|---|
| 1 | ITGB1 | ITGB1 Entrez, Source | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 17 | 0.364 | 0.0778 | Yes |
| 2 | TSPAN4 | TSPAN4 Entrez, Source | tetraspanin 4 | 42 | 0.304 | 0.1253 | Yes |
| 3 | ACTG1 | ACTG1 Entrez, Source | actin, gamma 1 | 50 | 0.290 | 0.1990 | Yes |
| 4 | TIAL1 | TIAL1 Entrez, Source | TIA1 cytotoxic granule-associated RNA binding protein-like 1 | 74 | 0.252 | 0.2325 | Yes |
| 5 | CAP1 | CAP1 Entrez, Source | CAP, adenylate cyclase-associated protein 1 (yeast) | 103 | 0.217 | 0.2467 | Yes |
| 6 | KCNH2 | KCNH2 Entrez, Source | potassium voltage-gated channel, subfamily H (eag-related), member 2 | 143 | 0.176 | 0.2289 | Yes |
| 7 | BMP1 | BMP1 Entrez, Source | bone morphogenetic protein 1 | 165 | 0.147 | 0.2348 | Yes |
| 8 | SHC1 | SHC1 Entrez, Source | SHC (Src homology 2 domain containing) transforming protein 1 | 170 | 0.144 | 0.2704 | Yes |
| 9 | ITGA3 | ITGA3 Entrez, Source | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | 204 | 0.110 | 0.2437 | No |
| 10 | CDH1 | CDH1 Entrez, Source | cadherin 1, type 1, E-cadherin (epithelial) | 227 | 0.094 | 0.2320 | No |
| 11 | PIK3R3 | PIK3R3 Entrez, Source | phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma) | 323 | 0.015 | 0.0656 | No |
| 12 | ICAM4 | ICAM4 Entrez, Source | intercellular adhesion molecule 4 (Landsteiner-Wiener blood group) | 347 | -0.002 | 0.0248 | No |
| 13 | SRC | SRC Entrez, Source | v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) | 386 | -0.030 | -0.0345 | No |
| 14 | ITGB4 | ITGB4 Entrez, Source | integrin, beta 4 | 422 | -0.065 | -0.0783 | No |
| 15 | MPZL2 | 427 | -0.068 | -0.0652 | No | ||
| 16 | RASA1 | RASA1 Entrez, Source | RAS p21 protein activator (GTPase activating protein) 1 | 444 | -0.076 | -0.0715 | No |
| 17 | KRT31 | KRT31 Entrez, Source | keratin 31 | 455 | -0.098 | -0.0601 | No |
| 18 | COL16A1 | COL16A1 Entrez, Source | collagen, type XVI, alpha 1 | 480 | -0.123 | -0.0666 | No |
| 19 | CDH11 | CDH11 Entrez, Source | cadherin 11, type 2, OB-cadherin (osteoblast) | 502 | -0.138 | -0.0635 | No |
| 20 | ICAM2 | ICAM2 Entrez, Source | intercellular adhesion molecule 2 | 506 | -0.142 | -0.0267 | No |
| 21 | GAMT | GAMT Entrez, Source | guanidinoacetate N-methyltransferase | 523 | -0.167 | -0.0057 | No |
| 22 | ITGA10 | ITGA10 Entrez, Source | integrin, alpha 10 | 525 | -0.167 | 0.0424 | No |
| 23 | PKD1 | PKD1 Entrez, Source | polycystic kidney disease 1 (autosomal dominant) | 527 | -0.172 | 0.0917 | No |
